The Triple Satiety Hormone Activator
You’re on Ozempic and Wegovy, What’s Next?
Many people are losing large amounts of weight very quickly, and it is very likely that someone you know, see around town, or follow on social media is one of them. In most cases, this kind of dramatic change after years of being overweight is not happening just from “doing Pilates every day” or “cutting out carbs.”Why so much rapid weight loss?
More and more friends, acquaintances, celebrities, and even strangers are using GLP‑1 medications to change their bodies, often in sudden and sometimes extreme ways. For many, these drugs can be life‑changing, especially when they also improve heart health, lower inflammation, ease chronic pain, and support self‑image and confidence.
At the same time, these medications are not perfect and do come with important drawbacks that need to be weighed carefully.
Limits of traditional weight-loss options
- “Eat less, move more”: This approach has a very high long‑term failure rate and does not address how the body fights weight loss by increasing hunger and slowing metabolism.
- Bariatric surgery: While effective, it is a major procedure that requires lifelong diet changes, carries risks of nutrient deficiencies and digestive issues, and cannot be scaled to the millions of people who could benefit from weight loss.
- GLP‑1 medications: These drugs work well but can cause significant side effects, are expensive, and often lead to weight regain when stopped suddenly.
The rise of Ozempic, Wegovy, Mounjaro and Zepbound
Among today’s weight‑loss tools, GLP‑1 medications are currently the most effective and durable — as long as a person stays on them. In this practice, a prescription GLP‑1‑based program is offered with careful, individualized monitoring to make the process as safe and strategic as possible.
How our GLP‑1 weight loss program works
- Close tracking: Muscle mass, visceral fat, pancreatic enzymes, and the pace of weight loss are monitored to avoid changes that are too fast or extreme.
- Nutrition and exercise: Personalized food plans, adequate protein targets, and specific exercise guidance are provided to help preserve skeletal muscle, which is known to drop significantly on these medications.
- Regular lab work: Every three months, labs are checked, including liver and pancreatic enzymes, cholesterol and triglycerides, fasting glucose, insulin, hemoglobin A1c, and markers of inflammation.
- Maintenance planning: Once the target weight is reached, a customized plan is built to use the lowest effective dose needed to maintain a healthy body weight.
- Relapse prevention: Additional strategies are added to reduce the common rebound weight gain that can occur when GLP‑1 medications are stopped abruptly.
What GLP‑1 maintenance can look like
There are still only a few good options that can fully replace GLP‑1s for long‑term weight‑loss maintenance. To reduce dependence on full‑dose GLP‑1s, combination approaches are being used that pair lower doses of these medications with other supportive therapies, each chosen to help maintain weight loss without long‑term reliance on high‑dose injections.
Here are some supports that we have found to be very helpful in maintaining weight loss:
Reducore
Reducore is a formula designed to support metabolic health, blood sugar balance, muscle maintenance and healthy body composition. It combines clinically studied fibers, polyphenols, the amino acid leucine, and other nutrients to help reduce appetite, lower blood sugar, burn fat, support muscle, and assist with weight loss. The typical dose is 1 capsule with each meal.Hunger GLP‑1
Hunger GLP‑1 is a patented dietary supplement that helps increase fullness and reduce sugar cravings. It contains a blend of plant glycosides and amino acids that support blood sugar balance and decrease the desire to eat, especially refined carbohydrates.Thermo GLP‑1
Thermo GLP‑1 is designed to activate brown fat (brown adipose tissue), which is the type of fat that burns calories to generate heat. By stimulating brown fat activity, it may help increase baseline metabolism and support fat breakdown and fat burning.GLP‑1 Probiotic (Pendulum)
GLP‑1 Probiotic is a targeted probiotic that uses specific strains of beneficial bacteria to naturally boost the body’s own GLP‑1 production. This can help with appetite regulation, blood sugar control, and signaling fullness to the brain, which may support long‑term weight maintenance.Calocurb PRO
Calocurb PRO is a fast‑acting, plant‑based supplement that works with the body’s natural hormone signals to help control appetite. It contains Amarasate, a clinically studied extract of New Zealand bitter hops, in a delayed‑release capsule that activates bitter taste receptors in the gut and triggers satiety hormones such as GLP‑1, CCK, and PYY, which can reduce hunger, cravings, and calorie intake. When taken 1 hour before meals twice daily, Calocurb PRO can be used as a stand‑alone weight‑loss aid or as an additional tool during GLP‑1 maintenance.MGP Fiber
MGP Fiber is a next‑generation fiber supplement formulated to support a healthy gut microbiome, enhance fullness, and assist with weight management. Each serving provides about 11 grams of gentle, well‑tolerated fiber to support regular bowel function and satiety.CM Core
CM Core combines berberine and alpha‑lipoic acid (ALA) to support cardiovascular health, metabolism, and healthy lipid and glucose levels. It is often recommended for individuals with prediabetes or insulin resistance as a non‑pharmaceutical support for weight loss and metabolic health. Dosing is 1-3 capsules daily.Inflammacore
Inflammacore is an advanced nutritional formula created to address immune challenges, systemic inflammation, and gut barrier integrity. Because chronic inflammation can contribute to weight‑loss resistance, Inflammacore is often used as an adjunct to help calm inflammation and support more effective weight management. Dosing is about 1-2 scoops daily in liquid.Low‑Dose Naltrexone (LDN)
Low‑Dose Naltrexone is a compounded, low‑dose version of the prescription medication naltrexone, which at standard doses is used for opioid and alcohol dependence. At much smaller doses, it may help modulate the immune system, reduce inflammation, and influence appetite regulation, making it a potential tool in a comprehensive weight‑management plan under medical supervision.Wellbutrin
Wellbutrin is a prescription antidepressant and anti‑anxiety medication that affects certain brain chemicals (neurotransmitters), including norepinephrine. By increasing norepinephrine at the synapse, it may help reduce appetite and slightly increase metabolism, which can lead to weight loss in some people, but it can also cause side effects such as weight gain, insomnia, anxiety, jitteriness or restlessness, dry mouth, or tremor, and can create medication dependence in some patients.How can these supports be used to maintain or create optimal weight loss goals?
These supports can help people reach and maintain healthy weight goals by easing the “off‑ramp” from GLP‑1 drugs, reducing cravings and hunger, and sometimes allowing for lower GLP‑1 doses while preserving results.Transitioning off GLP‑1
When someone uses GLP‑1 medications, the body’s own GLP‑1 production can drop, which is one reason weight often rebounds when the drug is stopped. Using targeted supplements that stimulate natural GLP‑1 and other satiety hormones may help re‑engage the gut‑brain axis and soften this rebound. ✓ Bitter‑hops products like Calocurb (Amarasate) activate bitter receptors in the small intestine, which increases natural GLP‑1, CCK, and PYY and can cut hunger by about 30%, cravings by 40%, and calorie intake by roughly 18% in the short term. This makes Calocurb in combination with other natural supports, a practical “off‑ramp” tool as GLP‑1 injections are tapered, helping patients stay in control of appetite and portion sizes while doses are reduced or discontinued.Alternative to GLP‑1
For patients who cannot or do not want to use GLP‑1 medications, these supports can partially mimic some of the appetite and satiety benefits. ✓ Natural GLP‑1 activators (like Amarasate‑containing products) and gut‑driven satiety tools target the same gut–brain pathways that signal fullness, helping reduce cravings, snacking, and overall calorie intake. ✓ By lowering hunger and carb cravings, patients are better able to follow nutrition plans, maintain a calorie deficit, and protect their progress without injections.Adjunct with GLP‑1
These same tools can also be layered on top of GLP‑1 treatment to improve comfort, adherence, and sometimes dose requirements. ✓ In clinical studies, Amarasate‑based products taken about an hour before eating increased natural GLP‑1 release and led to an average 18% reduction in calorie intake at the following meal. ✓ Some clinicians report that when appetite is better controlled with these adjuncts, patients can stay comfortable on lower GLP‑1 doses, which may reduce side effects and long‑term medication burden while preserving weight‑loss momentum.
Summing It Up
- Although there are several successful weight loss interventions available, there are some concerns about using these powerful medications long term.
- Adding in targeted natural supportive supplements can help people reach and maintain healthy weight by targeting appetite, cravings, metabolism, and inflammation in a coordinated way.
- These supports are especially useful when transitioning off GLP‑1 medications, because they can help reactivate the gut–brain axis, boost natural GLP‑1 and other satiety hormones, and reduce the rebound hunger that often leads to weight regain.
- For those who cannot or prefer not to use GLP‑1s, these tools can offer a partial alternative by lowering cravings and calorie intake so it is easier to stay on track with nutrition and lifestyle plans.
- They can also be layered alongside GLP‑1 therapy to improve appetite control and, in some cases, allow for lower medication doses while still supporting effective, sustainable weight loss.
We are happy to help. Reach out to us for more information about our weight loss programs and to find the best options available for your health care goals.
Please Share the Health if you liked what you read!!!
For more information about my wellness programs and my practice, check out my website drsadaty.com. Hey Look! You are already here… Ready for the legal disclaimer? Information offered here is for educational purposes only and does not constitute medical advice. As with any health recommendations, please contact your doctor to be sure any changes you wish to consider are safe for you!Mental Health Hormones Doctor Anita Sadaty Share The Health board certified gynecologist New York Functional Medicine NY Women’s Wellness